Pharmacokinetics and Pharmacodynamics
Pharmacokinetic and pharmacodynamic parameters become important because of the association between host drug concentrations, microorganism eradication, and resistance.The Pharmaceutical industry's long successful strategy of placing big bets on a few molecules, promoting them heavily and turning them into blockbusters worked well for many years, but its R&D productivity has now plummeted and the environment’s changing.
· Drug biotransformation reactions
· Pharmacokinetic aspects
· Drug interactions and pharmacological compatibilities
· Clinical efficacy and safety evaluation