Molecular and Cellular Pharmacology
In this module you will contemplate molecular pharmacology and signal transduction pathways (particularly those managed by GPCRs), including their structure and capacity in various cells and tissues. Inside this system we will consider the different methodologies that have been effectively utilized pharmacologically to control diverse parts of these pathways and investigate future procedures to the treatment of various ailments. Notwithstanding considering established pathways downstream of GPCRs (e.g. cyclic AMP/cyclic AMP-subordinate protein kinase, IP3/Ca2+, DAG/protein kinase C, and so forth.), we will look at how changed receptor super families manage chemicals/pathways, for example, phosphoinositide 3-kinase, mitogen-actuated protein kinases and translation factors. We will likewise consider different parts of receptor direction (e.g. receptor desensitization and disguise). All through the module we will talk about the most recent research in sub-atomic and cell pharmacology/cell flagging, looking specifically at new pharmacological ways to deal with treating illness.
· Basic structures and functions of receptors
· key components of signal transduction cascades
· Signalling pathways
· Pharmacological manipulation of receptors
· Regulation of receptors